Category Archives: Defenses

Our student Doriana Orbanić defended her Thesis

Category : Defenses

On November 19th, our student Doriana Orbanić presented her thesis entitled «MULTIFUNCTIONAL TUNABLE ELASTIN-LIKE RECOMBINAMER-BASED HYDROGELS CUSTOMIZED FOR NEOVASCULARISATION AND DYNAMIC CELL NICHE CONSTRUCTION PURPOSES», developed under the supervision of Prof. José Carlos Rodríguez Cabello and Prof. Matilde Alonso Rodrigo.

The work presented results regarding the development of promising chemically crosslinked hydrogels aimed to be applied for soft tissue regeneration purposes, showing a step forward in the modularity of the system, in comparison to previous studies, and an interesting combination of bioactivities. The biomaterials developed revealed appreciable results in regard to their mechanical features and in in vitro cell culture studies, but also remarkably exhibited outstanding results in in vivo studies. Moreover, a more fundamental study of hybrid silk-elastin like recombinamers has been presented to elucidate more in detail events taking place at a nano- and micro- scale within the system and the possible application of the hydrogels obtained through physical crosslinking for the construction of cell niches. The novel elastin-like recombinamer-based hydrogels presented have exceptional properties and shall be further studied for specific applications.

Well done Doriana! We wish you all the best!


Our student Filippo Cipriani defended his thesis

Category : Defenses

On October 4th, our student Filippo Cipriani presented his thesis entitled «ENGINEERING RESPONSIVE AND BIOMIMETIC MATERIAL BASED ON ELASTIN-LIKE RECOMBINAMERS FOR BIOMEDICAL APPLICATION» under the supervision of  Prof. José Carlos Rodríguez Cabello and Prof. Israel González de Torre.

In his Thesis, Filippo estudied the ELRs technology with its outstanding properties; the leitmotiv is represented by the development of engineering material in a sort of journey towards the exploration of new possibilities, mashing approaches and crossing boundaries. This Thesis is composed by several chapters regarding the development of novel Biomaterials. Two different gelation mechanisms for hydrogel formation has been explored in order to address the complex issue of Tissue Regeneration for Cartilage and Bone. Moreover, several ELR-designs have been explored for the generation of new classes of smart Biomaterials.

Well done Filippo! We wish you all the best!


Our student Tatjana Flora defended her thesis

Category : Defenses

On June 26th, our student Tatjana Flora presented her thesis entitled «Bioenfineered Dynamic Systems based on Elastin-like -Recombinamers» under the supervision of Prof. José Carlos Rodríguez Cabello and Prof. Matilde Alonso Rodrigo.

In her Thesis, Tatjana developed bioengineered systems based on Elastin-like recombinamers for their application in biomedical area.

Well done Tati! We wish you all the best!


Our student Constancio González Obeso has defended his thesis

Category : Defenses

On May 4th, our student Constancio González presented his thesis named «Study of the properties and applications of silk elastin-like recombinamers» under the supervision of  Prof. José Carlos Rodríguez Cabello and Prof. Alessandra

In his Thesis, Constancio developed several Elastin Like Recombinamers based on silk domains for their use into different applications such as mucoadhesion and wound healing.

Well done Ito! we wish you the best!


Our student Arturo Ibáñez Fonseca defended his thesis

Category : Defenses

Arturo Ibáñez Fonseca defended his thesis, entitled “Novel hydrogel-forming elastin like recombinamers for biomedical applications”, on the 24th of November 2017. In his thesis, carried out under the supervision of Fco. Javier Arias Vallejo and Matilde Alonso Rodrigo, Arturo studied the biocompatibility of ELR-based hydrogels to use them in the tissue engineering and regenerative medicine field. Specifically, he showed that these hydrogels promoted bone regeneration in vivo. Moreover, fluorescent hydrogels were also obtained, showing a Förster resonance energy transfer (FRET) when ELRs genetically fused to two different fluorescent proteins were combined to form the hydrogels. In summary, his thesis sheds light on the use of ELRs in biomedical applications.

Congratulations Arturo, we wish you the best!!


Our student Mohammed Hamed Misbah defend his thesis

Category : Defenses

On July 11th, our student Mohammed Hamed Misbah presented his thesis named «Controlled Formation of Nanostructures Based on Elastin-like Recombinamers» It was carried out under the supervision of  Prof. José Carlos Rodríguez Cabello and Prof. Luis Quintanilla Sierra.

In his Thesis, Mohammed study the synergistic combination between multiple and outstanding properties stemmed from different materials: elastin-like recombinamers (ELRs) inspired by natural elastin, calcium phosphate and carbon nanotubes (CNTs). Understanding of such fundamental processes aims to construct new ELRs and develop new functional materials, thus transferring new ideas to artificial materials and different applications.

Well done Mohammed! we wish you the best!

 

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Our student María Jesús Piña defend her thesis

Category : Defenses

María Jesús Piña defended her thesis on the 24th of June. It was entitled «ELR-based nanocomplexes with potential biomedical uses».

In her thesis, carried out under the supervision of  Fco. Javier Arias Vallejo and José Carlos Rodríguez Cabello, she focused in the design and application of novel ELR nanocomplexes for drug and gene delivery. Along her thesis, ELR biomaterials have been used for cancer treatment, and specifically for breast cancer as final goal.

Congratulatios Chus, we wish you the best !!

 

 

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Alicia, our favourite student from Zamora defend her Thesis on the 22 of February

Category : Defenses

Alicia’s thesis entitled «Thermosensitive injetable hydrogels with enhanced stability based on elastin, silk and leucine zipper motifs for tissue engineering and drug delivery applications», was carried out under the supervision of Matilde Alonso and Javier Arias.

In her Thesis, Alicia explores the properties and applications of two new sequences of Elastin like polymers, containing the Silk and Zipper motifs, that showed the ability to form physical hydrogels.

Congratulatios Alicia!!

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Congratulations to our Dr. Guillermo Pinedo for successfully defending his Ph.D. thesis on July 16 2014

Category : Defenses

His work entitled: “Development of Nanostructures and Highly Functional Systems with Complex Molecular Architecture Based on Elastin-Like Recombinamers” was carried out under the direction of Matilde Alonso Rodrigo and José Carlos Rodríguez Cabello. Best wishes Gui!


Congratulations to María del Carmen García Arévalo for winning the PhD Award of 2012

Category : Defenses

Congratulations for winning the PhD Award of 2012 in the best PhD thesis competition of the University of Valladolid in the Health Sciences Area. Her thesis titled “Elastin-Like Recombinamers for Advanced Biomedical Applications: Tissue Engineering, Gene Delivery and Nanovaccines” was carried out in our group BIOFORGE, under the direction of Francisco Javier Arias Vallejo and José Carlos Rodríguez Cabello