You can review our publications in the following years:



A. Ibáñez-Fonseca, T. L. Ramos, I. González de Torre, L. I. Sánchez-Abarca, S. Muntión, F. J. Arias, M. C. del Cañizo, M. Alonso, F. Sánchez-Guijo, J. C. Rodríguez-Cabello. “Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical crosslinking for various applications in tissue engineering and regenerative medicine”. Journal of Tissue Engineering and Regenerative Medicine (2017, in press)

D. S. Bilecen, J. C. Rodriguez-Cabello, H. Uludag, V. Hasirci. “Construction of a PLGA Based, Targeted siRNA Delivery System for Treatment of Osteoporosis”. Journal of Biomaterials Science: Polymer Edition (in press)

D. Pescador, A. Ibáñez-Fonseca, F. Sánchez-Guijo, J. G. Briñón, F. J. Arias, S. Muntión, C. Hernández, A. Girotti, M. Alonso, M. C. del Cañizo, J. C. Rodríguez-Cabello, J. F. Blanco. Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels. Journal of Materials Science: Materials in Medicine, 28(8):115 (2017). doi: 10.1007/s10856-017-5928-1

K . E. Inostroza-Brito, E. C. Collin, A. Poliniewicz, S. Elsharkawy, A. Rice, A. E. del Río Hernández, X. Xiao, J. C.  Rodríguez-Cabello, A. Mata. Cross-linking of a Biopolymer-Peptide Co-Assembling System“. Acta Biomaterialia (2017, in press)

F.J. Arias, S. Acosta-Rodríguez, T. Flora, S. Serrano-Dúcar. “Biomedical Applications of Recombinant Proteins and Derived Polypeptides”. In “Biopolymers for Medical Applications” Ruso, J.M. and Messina, PV. (Eds) CRC Press (Taylor and Francis Group) Boca Raton (USA) (2017). ISBN: 978-1-4987-4496-6

A. da Costa, A. Pereira, A. Gomes, J. C. Rodriguez-Cabello, V. Sencadas, M. Casal, R. Machado.“Single step fabrication of antimicrobial fibre mats from a bioengineered protein-based polymer”. Biomedical Materials, 12;12(4):045011 (2017). doi: 10.1088/1748-605X/aa7104.

E. Sayin, R. Hama Rashid, J. C. Rodríguez-Cabello, A. Elsheikh, E. Türker Baran, V. Hasirci. Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend. Bioactive Materials, 2, 2, 71-81 (2017).

S. Staubli, G. Cerino, I. Gonzalez De Torre, M. AlonsoD. Oertli, F. Eckstein, K. Glatz, J. C. Rodríguez Cabello, A. Marsano. Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel. Biomaterials, 135,  30-41 (2017).

J. Coletta, A. Ibáñez-Fonseca, L. R. Missana, M. V. Jammal, E. J. Vitelli, M. Aimone, F. Zabalza, J. P. Mardegan Issa, M. Alonso, J. C. Rodríguez-Cabello, S. Feldman. “Bone regeneration mediated by a bioactive and biodegradable ECM-like hydrogel based on elastin-like recombinamers”. Tissue Engineering Part A (2017, in press)

M. P. Sousa , I. Gonzalez de Torre,  M. B. Oliveira,  J. C. Rodríguez-Cabello, J. F. Mano.Biomimetic click assembled multilayer coatings exhibiting responsive properties”. Materials Today Chemistry (2017, in press)

M. Hamed Misbah, M.Santos, L. Quintanilla, C. Günter, M. Alonso, A. Taubert, J. C. Rodríguez-Cabello. Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralizationBeilstein Journal of Nanotechnology, 8, 772–783 (2017). doi:10.3762/bjnano.8.80

F.J. Arias, M. Santos, A. Ibáñez-Fonseca, MªJ. Piña, S. Serrano, “Elastin-like recombinamers as smart drug delivery systems” Current Drug Targets (2017) DOI: 10.2174/1389450117666160201114617

M.Santos, C. González-Obeso, D. Orbanic, E. Pérez del Río, F.J. Arias, Advanced systems for controlled drug delivery from chemically modified Elastin-like Recombinamers Current Organic Chemistry 21: 21-33 (2017). doi: 10.2174/1385272820666160511120925

A. Ibáñez-Fonseca, M. Alonso, F. J. Arias, J. C. Rodriguez-Cabello, “FRET-paired hydrogel forming silk-elastin-like recombinamers by recombinant conjugation of fluorescent proteinsBioconjugate Chemistry, 28 (3), pp 828–835 (2017). doi: 10.1021/acs.bioconjchem.6b00738

J. P. Govindarahjulu, X. Chen, Y. Li, J. C. Rodriguez-Cabello, M. Battacharya, C.Aparicio. Chitosan-recombinamer layer-by-layer coatings for multifunctional implants”. International Journal of Molecular Sciences (2017Accepted for Publication)

Y. Li, J. C. Rodríguez-Cabello, C. Aparicio. “Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils. ACS Applied Materials & Interfaces (2017, in press). doi: 10.1021/acsami.6b15285


MPutzu, F. Causa, V. Nele, I. G. de Torre, J. C. Rodriguez-Cabello, P. A. Netti.Elastin-like-recombinamers multilayered nanofibrous scaffolds for cardiovascular applications. Biofabrication; 15;8(4):045009 (2016). doi: 10.1088/1758-5090/8/4/045009

13-Coacervation of elastin-like recombinamer microgels

S. Singh, D.E. Demco, K. Rahimi, R. Fechete, J.C. Rodriguez-Cabello, M. Möller.Coacervation of elastin-like recombinamer microgelsMacromolecular Rapid Communications;37(2):181-6 (2016). doi: 10.1002/marc.201500457

B. Barriuso,  P. Antolin,  F.J Arias F,  A. Girotti A,  P. Jimenez,  M. Cordoba-Diaz,  D. Cordoba-Diaz,  T. Girbes. “Anti-Human endoglin (hCD105) immunotoxin— Containing recombinant single chain ribosome- Inactivating protein musarmin”Toxins, 8, Issue 6 (2016)

A. Fernandez-Colino,  J.M. Bermudez,  F.J. Arias, D. Quinteros, E. Gonzo. “Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel”Materials Science and Engineering, 61, 286 – 292 (2016)

S. Poveda-Reyes, V. Moulisova, E. Sanmartín-Masiá, L. Quintanilla-Sierra, M. Salmerón-Sánchez, G. G. Ferrer. “Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation”. Macromol Biosciences; 16(9):1311-24 (2016) doi: 10.1002/mabi.201500469.

J.C. Rodríguez Cabello, I. González De Torre, M. Santos, A.M. Testera, M. Alonso. Chemical Modification of Biomaterials from Nature. In: Biomaterials from Nature for Advanced Devices and Therapies, pp.444-474. 2016. DOI: 10.1002/9781119126218.ch24

R. Kovacina, W. F. Daamen, D. Orbanić, J. C.s Rodríguez-Cabello, A. S Weiss. Elastin Biopolymers. In: Reference Module in Materials Science and Materials Engineering. 2016. DOI 10.1016/B978-0-12-803581-8.10187-0

Elastin-like polypeptides in drug delivery


J. C. Rodríguez-Cabello, F. J. Arias, M. Alonso, A. Girotti. Elastin-like polypeptides in drug deliveryAdvanced Drug Delivery Reviews 97, 85–100 (2016)

2016 (2)M. J. Piña, A. Girotti, M. Santos, J.C. Rodríguez-Cabello, F. J. Arias.Biocompatible ELR based polyplexes coated with MUC1 specific aptamers and targeted for breast cancer gene therapyMol Pharm, 13 (3), pp 795–808 (2016). doi: 10.1021/acs.molpharmaceut.5b00712


mohammedM. Hamed Misbah,  M. Espanol, L. Quintanilla, M. P. Ginebra, J. Carlos Rodríguez-Cabello. Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamersRSC Adv, 6, 31225 (2016)


S. Singh, Dan E. Demco, K. Rahimi, R. Fechete, J. C. Rodríguez-Cabello, M. Möller.  Aggregation behaviour of biohybrid microgels from elastin-like recombinamerSoft Matter, 2016, Accepted Manuscript. doi: 10.1039/C6SM00954A.

I. Gonzalez de Torre, M. Weber, L. Quintanilla, M. Alonso, S. Jockenhoevel, J. C. Rodríguez Cabello, P. Mela. Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications. Biomater Sci. 2016; 4(9):1361-70. doi: 10.1039/c6bm00300a


M. Vila, A. García, A. Girotti, M. Alonso, J. C. Rodríguez-Cabello, A. González-Vázquez, J. A. Planell, E. Engel, J. Buján, N. García-Honduvilla, M. Vallet-Regí. 3D Silicon doped hydroxyapatite scaffolds decorated with elastin-like recombinamers for bone regenerative medicineActa Biomaterialia. 2016; 45: 349–356. Doi: 10.1016/j.actbio.2016.09.016



M. Weber, I. Gonzalez de Torre, R. Moreira,  J. Frese, C. Oedekoven, M. Alonso,  C. J. Rodriguez Cabello, S. Jockenhoevel, P. Mela. “Multiple-Step Injection Molding for Fibrin-Based Tissue-Engineered Heart Valves”Tissue engineering: Part C, 21, 8 (2015)

X. Punet, R. Mauchauffé, M. Alonso, J. C. Rodríguez-Cabello, E. Engel, M. A. Mateos-Timoneda. “Biomolecular functionalization for enhanced cell-material interactions of poly (methyl methacrylate) surfaces”. Regenerative Biomaterials, 2015, 1-9. doi:10.1093/rb/rbv014

M. H. Misbah, L. Quintanilla, M. Alonso, J.C. Rodríguez-Cabello. “Evolution of Amphiphilic Elastin-like co-Recombinamer Morphologies From Micelles to a Lyotropic Hydrogel”Polymer 81, 37–44 (2015). doi:10.1016/j.polymer.2015.11.013

Y. Li, X. Chen, A. Fok, J.C. Rodriguez-Cabello, and C. Aparicio. Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Density. ACS Appl. Mater. Interfaces, 7(46): 25784-92. doi: 10.1021/acsami.5b07628

8-Amphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers. Cooperative Interplay between Both Domains Results in Injectable and Stable Hydrogels

A. Fernández-Colino, F. Javier Arias, M. Alonso, and J. Carlos Rodríguez-Cabello. Amphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers: Cooperative Interplay between Both Domains Results in Injectable and Stable HydrogelsBiomacromolecules, 16 (10), pp 3389–3398 (2015). doi: 10.1021/acs.biomac.5b01103.

A. Sánchez-Ferrero, A. Mata, M.A. Mateos-Timoneda, J.C. Rodríguez-Cabello, M. Alonso, J. Planell, E. Engel.Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regenerationBiomaterials, 68, 42-53 (2015). doi:10.1016/j.biomaterials. 2015.07.062 Epub 2015 Aug 3.

10-Exploring the properties of genetically engineered silk-elastin-like protein films

R. Machado, A. da Costa, V. Secadas, A.M. Pereira, T. Collins, J.C. Rodríguez-Cabello, S. Lanceros-Méndez, M. Casal.Exploring the properties of genetically engineered silk-elastin-like protein filmsMacromolecular Bioscience (2015). doi: 10.1002/mabi.201500132.


6-Recombinant technology in the development of materials and systems for soft-tissue repair


A. Girotti, D. Orbanic, A. Ibáñez-Fonseca, C. González-Obeso, J.C. Rodríguez-Cabello.Recombinant technology in the development of materials and systems for soft-tissue repairAdv Healthc Mater (2015). doi: 10.1002/adhm.201500152.


9- Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers

J.C. Rodríguez-Cabello, M. Jesús Piña, A. Ibáñez-Fonseca, A. Fernández-Colino, and F.J. Arias.Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers. Bioconjugate Chem., 26 (7), pp 1252–1265 (2015), doi: 10.1021/acs.bioconjchem.5b00183.


K. Inostroza Brito, E. Collin, O. Siton-Mendelson, K. Smith, A. Monge-Marcet, D. Ferreira, R.Pérez Rodríguez, M. Alonso, J.C. Rodríguez-Cabello, R.Reis, F. Sagués, L. Botto, R. Bitton, H. Azevedo, and A. Mata.Co-assembly, spatio-temporal control, and morphogenesis of a hybrid protein/peptide system. Nature Chemistry 7, 897–904 doi:10.1038/nchem.2349

[Video] [Chemistryworld] []

V.E. Santo, S. Prieto, A.M. Testera, F.J. Arias, M. Alonso; J.F. Mano, J.C. Rodríguez-Cabello.Temperature-responsive bioactive hydrogels based on a multifunctional recombinant elastin-like polymerBiomaterials and biomedical engineering, 2 (1), 47-59 (2015). doi: http ://

M.J. Piña, S.M. Alex, F.J. Arias, M. Santos, J.C. Rodriguez-Cabello, R.M. Ramesan, C.P. Sharma. Elastin-like recombinamers with acquired functionalities for gene-delivery applicationsJounal of Biomedical Materials Research part. A. (2015), doi: 10.1002/jbm.a.35455.

A.M Testera, A. Girotti, I. González de Torre, L. Quintanilla, M. Santos,  M. Alonso, J.C. Rodríguez-Cabello.Biocompatible elastin-like click gels: design, synthesis and characterization. Journal of Materials Science: Materials in Medicine, 26 (2), 5435 (2015). doi:10.1007/s10856-015-5435-1.

3-Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applicationsM.I. Castellanos, A.-S. Zenses, A. Grau, J.C. Rodríguez-Cabello, F.J. Gil, J.M. Manero, M. Pegueroles.Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applicationsColloids and Surfaces B: Biointerfaces, 127, 22-32 (2015). doi: 10.1016/j.colsurfb.2014.12.056.

1-Elastin like recombinamer-covered stents. Towards a fully biocompatible and non-thrombogenic device for cardiovascular diseasesI. González de Torre, F. Wolf, M. Santos, L. Rongen, M. Alonso, S. Jockenhoevel, J.C. Rodríguez-Cabello, P. Mela.Elastin-like recombinamer-covered stents: towards a fully biocompatible and non-thrombogenic device for cardiovascular diseasesActa Biomaterialia, 12, 146-155 (2015). doi: 10.1016/j.actbio.2014.10.029.


Image for unlabelled figureA. Fernández-Colino, J. M. Bermudez,F. J. Arias, D. Quinteros, E. Gonzo.“Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel”Mater Sci Eng C Mater Biol Appl. 61, 286-92 (2016). doi: 10.1016/j.msec.2015.12.050.



E. Tejada-Montes, K.H. Smith, E. Rebollo, R. Gómez, M. Alonso, J.C. Rodriguez-Cabello, E. Engel, A. Mata. “Bioactive membranes for bone regeneration applications: effect of physical and biomolecular signals on mesenchymal stem cell behaviour”Acta Biomaterialia, 10, 134-141 (2014).

E. Salvagni, G. Berguig, E. Engel, J.-C. Rodriguez-Cabello, G. Coullerez, M. Textor, J.A. Planell, F.Javier Gil , Conrado Aparicio. A Bioactive Elastin-like Recombinamer Reduces Unspecific Protein Adsorption and Enhances Cell Response on Titanium Surfaces. Colloids and Surfaces B: Biointerfaces, 114, 225-233 (2014).

F. J. Arias, M. Santos, A. Fernandez-Colino, G. Pinedo and A. Girotti. “Recent contributions of elastin-like recombinamers to biomedicine and nanotechnology. Current Topics in Medicinal Chemistry, 14 (6), 819-36 (2014).

C. Kilic, A. Girotti, J.C. Rodriguez-Cabello, V. Hasirci. “A collagen-based corneal stroma substitute with micro-designed architecture”Biomaterials Science, 2, 318-329 (2014).

I. Gonzalez de Torre, A. Testera, L. Quintanilla, M. Santos, M. Alonso, J.C. Rodriguez-Cabello. “Elastin-like recombinamers catalyst-free click gels (ELRs-CFCGs).I: Characterization of poroelastic and intrinsic viscoelastic properties”Acta Biomaterialia, 10(6), 2495-505 (2014).

Rui R Costa, Alessandra Girotti, Mercedes Santos, Javier Arias, Joao F. Mano, J. Carlos Rodríguez-Cabello. “Cellular Uptake of Multilayered Capsules Produced With Natural and Genetically Engineered Macromolecules”Acta Biomaterialia, 10 (6), 2653-2662 (2014). doi: 10.1016/j.actbio.2014.02.020.

Yuping Li, Xi Chen, Artur J. Ribeiro, Eric D. Jensen, Kyle V. Holmberg, J.Carlos.Rodriguez-Cabello, C. Aparicio. “Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers”Advanced Healthcare Materials, 3 (10), 1638-1647 (2014). 2014 Best Paper of the Year Award in Basic Sciences at the University of Minnesota School of Dentistry.

G. Pinedo-Martín, E. Castro, L. Martín, M. Alonso, J.C. Rodriguez-Cabello. “The effect of surfactants on the self-assembly of a model elastin-like block co-recombinamer: From micelles to an aqueous two-phase system”Langmuir, 30(12), 3432-40 (2014). doi: 10.1021/la500464v.

E. Tejeda-Montes, A. Klymov, M. Reza Nejadnik, M. Alonso, J.C. Rodriguez-Cabello, X.F. Walboomers, A. Mata. Mineralization and Bone regeneration using a bioactive elastin-like recombinamer membrane”Biomaterials, 35, 8339-8347 (2014).

I. González de Torre, L. Quintanilla, G. Pinedo-Martín, M. Alonso, J.C. Rodriguez-Cabello. “Nanogel Formation from Dilute Solutions of Clickable Elastin-Like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes”ACS Applied Materials & Interfaces, 6(16), 14509-14515 (2014).

G. Pinedo-Martín, M. Santos, A.M. Testera, M. Alonso, J.C. Rodríguez-Cabello. “The Effect of NaCI on the Self-assembly of elastin-like block co-recombinamers: Tuning the size of micelles and vesicles”Polymer, 55, 5314-5321 (2014).

A. Fernández-Colino, F.J. Arias, M. Alonso, J.C. Rodriguez-Cabello. “Self-organized ECM-mimetic model based on an amphiphilic multiblock silk-elastin-like co-recombinamer with a concomitant dual physical gelation process”Biomacromolecules 15 (10), 3781-3793 (2014). doi: 10.1021/bm501051t 5.750.


Amar K. Singh, Girish K. Srivastava, Laura Martín, Matilde Alonso, J. Carlos Pastor. “Bioactive substrates for human retinal pigment epithelial cell growth from elastin-like recombinamers”. Journal of Biomedical Materials Research – Part A, Volume 102, Issue 3, 639-646 (2013)

M. Gonzalez, E. Salvagni, J.C. Rodriguez Cabello, E. Rupérez, Fco. J. Gil, J. Peña, J.M. Manero. “A low elastic modulus Ti-Nb-Hf alloy bioactivated with an elastin-like protein-based polymer enhances osteoblast cell adhesion and spreading”Biomed Mater Res Part A, 101 (3), 819-826 (2013). doi: 10.1002/jbm.a.34388.

Rui R. Costa, Artur J. Ribeiro, J.C. Rodriguez-Cabello, J.F. Mano. “Nanostructured thin coatingS from chitosan and an elastin-like recombinamer with acute stimuli-responsive behaviour”Advanced Materials Forum Vi, Pts 1 And 2. Book Series: Materials Science Forum, Vols. 730-732, 32-37 (2013).

C. García-Arévalo, J.F. Bermejo Martín, L. Rico, V. Iglesias, L. Martín, J.C. Rodriguez-Cabello, F.J. Arias.  Immunomodulatory nanoparticles form elastin-like recombinamers: single-molecules for tuberculosis vaccine development. Molecular Pharmaceutics, 10(2), 586-97 (2013). doi: 10.1021/mp300325v.

R. Machado, J. Azevedo-Silva, C. Correia, T. Collins, F.J. Arias, J.C. Rodríguez-Cabello, M. Casal. “High level expression and facile purification of recombinant silk-elastin-like polymers in auto induction shake flask cultures”AMB Express, 3(1), 11 (2013). doi: 10.1186/2191-0855-3-11.

R.R. Costa, C.A. Custódio, F.J. Arias, J.C. Rodríguez-Cabello, J.F. Mano. “Nanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules”Nanomedicine: Nanotechnology, Biology, and Medicine, 9, 895-902 (2013).

M. Pierna, M. Santos, F.J. Arias, M. Alonso, J.C. Rodriguez-Cabello. “Efficient cell and cell-sheet harvesting based on smart surfaces coated with a multifunctional and self-organizing Elastin-Like Recombinamer”Biomacromolecules, 14, 1893-1903 (2013).

R.R. Costa, A. Testera, F.J. Arias, J.C. Rodríguez-Cabello, J. Mano. “Layer-by-Layer Film-Growth Using Polysaccharides and Recombinant Polypeptides: A Combinatorial Approach”The Journal of Physical Chemistry B, 117(22), 6839-6848 (2013).

R.R. Costa, E. Castro, F.J. Arias, J.C. Rodríguez-Cabello, J. Mano. “Multifunctional Compartmentalized Capsules with a Hierarchical Organization from the Nano to the Macro Scales”Biomacromolecules, 14, 2403-2410 (2013).

X. Punet, R. Mauchauffé, M. Giannotti, J.C. Rodríguez-Cabello, F. Sanz, E. Engel, M.A. Mateos-Timoneda, J. Planell. “Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces”Biomacromolecules, 14 (8), 2690-2702 (2013).

R. Machado, A. da Costa, V. Sencadas, C. García-Arévalo, C. Costa, J. Padrao, A. Gomes, S. Lanceros-Mendez, J.C. Rodriguez-Cabello, M. Casal. “Electrospun silk-elastin-like fiber mats for tissue engineering applications”Biomedical Materials, 8 (6), 065009 (2013).


Laura Martín, Emilio Castro, Artur Ribeiro, Matilde Alonso,  J. Carlos Rodríguez-Cabello. “Temperature-Triggered Self-Assembly of Elastin-Like Block Co-Recombinamers:The Controlled Formation of Micelles and Vesicles in an Aqueous Medium”Biomacromolecules 13, 293−298 (2012).

Esther Tejeda-Montes, Katherine H. Smith, Marta Poch, María Jesús López-Bosque, Laura Martín, Matilde Alonso, Elisabeth Engel, Alvaro Mata. “Engineering membrane scaffolds with both physical and biomolecular signaling”Acta Biomaterialia 8, 998–1009 (2012).

C. Garcia-Arévalo, M. Pierna Alvarez, A. Girotti, F.J. Arias Vallejo, J.C. Rodriguez-Cabello. “A comparative study of cell behavior on energetic and bioactive different polymeric surfaces made from elastin-like recombinamers”Soft Matter, 8 (11), 3239-3249 (2012).

L. Martín, E. Castro, A. Ribeiro, M. Alonso, J.C. Rodriguez-Cabello.Temperature-Triggered Self-Assembly of elastin-like block co-recombinamers: the controlled formation of micelles and vesicles in aqueous medium”Biomacromolecules, 13, 293-298 (2012).

S. Nardecchia, M. Gutierrez, M. Ferrer, M. Alonso, I. Lopez, J.C. Rodríguez Cabello, F. del Monte. “Phase Behaviour of Elastin-Like Synthetic Recombinamers in Deep Eutectic Solvents”Biomacromolecules, 13(7), 2029-2036 (2012).


J.C. Rodriguez-Cabello, L. Martín, A. Girotti, C. García-Arévalo, F.J. Arias, M. Alonso. “Emerging Applications of Multifunctional Elastin-Like Recombinamers”Nanomedicine, Vol 6, 1, 111-122 (2011).

G.K. Srivastava, L. Martín, A.K. Singh, I. Fernandez-Bueno, M.J. Gayoso, M.T. Garcia-Gutierrez, A. Girotti, M. Alonso, J.C. Rodríguez-Cabello, J.C. Pastor. “Elastin-like recombinamers as substrates for retinal pigment epithelial (RPE) cell growth”Journal of Biomedical Materials Research: Part A, 97A, 243-250 (2011). doi: 10.1002/jbm.a.33050.

M. Golonka, M. Bulwan, M. Nowaskowska, A.M. Testera, J.C. Rodriguez-Cabello, S. Zapotoczny“Thermoresponsive multilayer films based on ionic elastin-like recombinamers”Soft matter, 7, 9402-9409 (2011).

S. Prieto, A. Shkilnyy, C. Rumplasch, A. Ribeiro, F.J. Arias, J.C. Rodriguez-Cabello, A. Taubert. Biomimetic calcium phosphate mineralization with multifunctional elastin-like recombinamers”Biomacromolecules.Vol 5, 1480-1486 (2011).

B. Kinikoglu, J.C. Rodríguez-Cabello, O. Damour, V. Hasirci. “A smart bilayer scaffold of elastin-like recombinamer and collagen for soft tissue engineering”J Mater Sci Mater Med., 22, 1541-1554 (2011).

J.C. Rodríguez-Cabello, M. Pierna, A. Fernández Colino, C. García-Arévalo, F.J. Arias Vallejo. “Recombinamers: Combining Molecular Complexity with Diverse Bioactivities for Advanced Biomedical and Biotechnological Applications”Advances in Biochemical Engineering/Biotechnology, 125, 145-179 (2011).

M.B. Oliveira, W. Song, L. Martín, S.M. Oliveira, S.G. Caridade, M. Alonso, J.C. Rodriguez-Cabello, J.F. Mano. “Development of an injectable system based on elastin-like recombinamer particles for tissue engineering applications”Soft Matter, 7, 6426-6434 (2011).

B. Kinikoglu, J.C, Rodríguez-Cabello, O. Damour, V. Hasirci. “The Influence of Elastin-like recombinant polymer significantly increases the self-renewing potential of a 3D tissue equivalent Derived From Human Lamina Propria Fibroblasts And Oral Epithelial Cells”Biomaterials, 32, 5756-5764 (2011).

R.R. Costa, F.J. Arias, J.C. Rodriguez-Cabello, J.F. Mano. “Temperature-responsive microcapsules prepared by nano-structured multilayers of chitosan and elastin-like recombinamer for the controlled release of therapeutic molecules”International journal of artificial organs, 34, 656-657 (2011).

R.R. Costa, C.A. Custódio, F.J. Arias, J.C. Rodríguez Cabello, J.F. Mano. “Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli responsive properties”. Small ,Vol. 7, 2640-2649 (2011). doi: 10.1002/smll.201100875.

A. Girotti, A. Fernández-Colino, I.M. López, J.C. Rodríguez-Cabello, F.J. Arias. “Elastin-like Recombinamers: Biosynthetic Strategies and Biotechnological Applications”Biotechnol J.,6 (10), 1174-1186 (2011). doi: 10.1002/biot.201100116.


P.C. Bessa, R. Machado, S. Nürnberger, D. Dopler, A. Banerjee, A.M. Cunha, J.C. Rodríguez-Cabello, H. Redl, M. van Griensven, R.L. Reis, M. Casal. “Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs”Journal of Controlled Release, 142, 312-318 (2010).

R. Alvarez-Rodríguez, F.J. Arias, M. Santos, A. M. Testera, J.C. Rodríguez-Cabello. Gold Tailored Photosensitive Elastin-Like Polymer: Synthesis of Temperature, pHand UV-VIS Sensitive Probes”Macromolecular Rapid Communications, 31, 568-573 (2010).

J.S. Barbosa, A.M. Testera, M. Alonso,F.J. Arias, J.C. Rodríguez-Cabello,J.F.Mano. “Development of Biomimetic Chitosan Based Hydrogels Using an Elastin Like Polymer”Advanced Engineering Materials, 12, B37-B44 (2010).

A. Fahmi, T. Pietsch, M. Bryszewsk, J.C. Rodríguez-Cabello, A. Koceva-Chyla, F.J. Arias, M. Alonso and N. Gindy. “Fabrication of CdSe-Nanofibres with Potential for Biomedical Applications”Advanced Functional Materials, 20, 1011-1018 (2010).

R. Álvarez-Rodriguez, M. Alonso, A. Girotti, V. Reboto, J.C. Rodríguez Cabello. “One pot Synthesis of pH and Temperature Sensitive Gold Clusters Mediated by a Recombinant Elastin-Like Polymer”European Polymer Journal, 46, 643-650 (2010).

L. Martín, F.J. Arias, M. Alonso, C. García-Arévalo and J.C. Rodríguez-Cabello.“Rapid micropatterning by temperature-triggered reversible gelation of a recombinant smart elastin-like tetrablock-copolymer”Soft Matter, 6, 1121-1124 (2010).


H. Martínez-Osorio, M. Juárez-Campo, Y. Diebold, A. Girotti, M. Alonso, J. Arias, J.C. Rodríguez-Cabello, C. García-Vázquez, M. Calonge.“Genetically engineered elastin-like polymer as a substratum to culture cells from the ocular surface”NCER: Current Eye Research. 34, 48-56. ISSN: 0271-3683 (2009).

Y. García, N. Hemantkumar, R. Collighan, M. Griffin, J.C. Rodriguez-Cabello and A. Pandit. “In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer”Tissue Engineering Part A Vol. 15, 4, 887-899 (2009). doi: 10.1089.

L. Martín, M. Alonso, M. Möller, J.C. Rodríguez-Cabello, P. Mela. “3D microstructuring of smart bioactive hydrogels based on recombinant elastin-like polymers”Soft Matter, 5, 1591-1593. doi: 10/1039/b823488d (2009).

R. Araujo, C. Silva, R. Machado, M. Casal, A. Cunha, J.C. Rodríguez Cabello, A. Cavaco-Paulo. “Proteolytic enzyme engineering: a tool for wool”Biomacromolecules, 10, 1655-1661 (2009).

A. Ribeiro, F. Javier Arias, J. Reguera, M. Alonso, J. C. Rodriguez-Cabello.Influence of the amino-acid sequence on the inverse temperature transition of elastin-like polymersBiophysycal Journal,Vol. 97, July, 312-320 (2009). ISSN: 0006-3495.

C. García-Arévalo, A. Girotti, F.J. Arias, S. Martín, I.M. López, J.C. Rodriguez-Cabello. “Obtención de un polímero de tipo Elastina modificado con secuencias Bioactivas y Biodegradables, para su aplicación en ingeniería”. Accésit a la mejor comunicación del XXXI Simposio de la Sociedad Ibérica de Biomecánica y Biomateriales. Biomecánica,17, 15-27 (2009).

R. Machado, A. J. Ribeiro, J. Padrão, D. Silva, A. Nobre, J. A. Teixeira, F. J. Arias, A. M. Cunha, J. C. Rodríguez-Cabello and M. Casal. “Exploiting the sequence of naturally occurring elastin: Construction, production and characterization of a recombinant thermoplastic proteinbased polymer”Journal of Nano Research 6, 133-145 (2009).

C.  Aparicio, E. Salvagni, M. Werner, E. Engel, M. Pegueroles, J.C. Rodríguez-Cabello, F. Muñoz, J.A. Planell, J. Gil. “Biomimetic Treatments on Dental Implants for Immediate Loading Applications”Journal of Medical Devices. Volume 3,  Issue 2, pag.27555 (2009).

N. Ozturk, A. Girotti, G. Torun Kose, J. C. Rodríguez-Cabello, V. Hasirci.Dynamic Cell Culturing and its Application to Micropatterned, Eslastin like Protein-Modified Poly(N-Isopropylacrylamide ) Scaffolds”Biomaterials, 30, 5417-5426 (2009).

J.S. Barbosa, R.R. Costa, A.M. Testera, M. Alonso, J.C. Rodríguez-Cabello, J.F. Mano. “Multi-layered Films Containing a Biomimetic Stimuli-Responsive Recombinant Protein”Nanoscale Research Letters, 4, 1247-1253 (2009).

R.R. Costa, C.A. Custódio, A.M Testera, F.J. Arias, J.C. Rodríguez-Cabello, N.M. Alves and J.F. Mano. “Stimuli-Responsive Thin Coatings Using Elastin-Like Polymers for Biomedical Applications”Advanced Functional Materials , 19, 3210-3218 (2009).

J.C. Rodríguez-Cabello, L .Martín, M. Alonso, F. Javier Arias, Ana M. Testera. “Recombinamers’’ as advanced materials for the post-oil age”Polymer.Vol. 50, Issue 22, 5159-5169 (2009). Invited Feature Paper.

L. Martín, M. Alonso, A. Girotti, F. Javier. Arias, J. C. Rodriguez-Cabello. “Synthesis and Characterization of Macroporous Thermo Sensitive Hydrogels from Recombinant Elastin-Like Polymers”Biomacromolecules, 10, 3015-3022 (2009). ID: bm-2009-00560a. R2.


Y. Garcia, H. Naik, R. Collighan, M. Griffin, J.C. Rodriguez-Cabello , A. Pandit. “Preferential cellular Behaviour is Seen with a Collagen-Elastin Like Polipeptide scaffold”.  Tissue Engineering Part A ISSN, 1937-3341, vol.14 – 5.pag. 769 (2008).

A. Girotti, F.J. Arias Vallejo, M Alonso, A.M. Testera, J. C. Rodriguez- Cabello. “Synthesis and Charactertization of Matrix Metalloprotease-Sensitive Elastin-Like Based Bioactive Hydrogels”Tissue Engineering Part A, ISSN 1937-3341, vol.14 – 5.pag.783-784 (2008).

R. R. Costa, A.M. Testera, F.J. Arias, J.F. Mano, J.C. Rodriguez-Cabello.Development of Biomimetic and Smart Coatings Based on Elastin-Like Polymers Coating RGD Cell Attachment sequences”Tissue Engineering Part A, ISSN 1937-3341, vol.14–5. pag.837 (2008).

J.S. Barbosa, A.M. Testera, M. Alonso, J.F. Mano, J.C. Rodriguez-Cabello. “Preparation of Temperature-responsive Matrices with Osteoinductive Behaviour Combining an Elastin-Like Polymer and Chitosan”Tissue Engineering Part A, ISSN 1937-3341, vol.14 – 5. pag.898 (2008).

V. Espírito Santo, S. Prieto, A. M. Testera, M. Alonso, F.J. Arias, J. F. Mano, J. C. Rodriguez-Cabello. “Physical Properties of an Artificial extracellular Matrix Based on a Crosslinked Elastin-like Polymer”Material Science Forum Vols. 587-588, 47-51 (2008).


D. Kurková, J. Kříž, J. C. Rodríguez-Cabello, and F. Javier Arias.NMR Study of a Cooperative Behavior of Thermotropic Model Polypeptides”Polymer International, 56 (2), 186-194 (2007). 

J. C. Rodríguez-Cabello, S. Prieto, J. Reguera, F. Javier Arias, A. Ribeiro.Biofunctional design of elastin-like polymers for advanced applications in nanobiotechnology”J. Biomater. Sci. Polymer Edn., 18(3), 269-286 (2007).

J. Reguera, D.W. Urry, T.M. Parker, D.T. McPherson, J.C. Rodríguez-Cabello.“Effect of NaCl on the Exothermic and Endothermic Components of the Inverse Temperature Transition of a Model Elastin-like Polymer”Biomacromolecules, 8(2), 354-358 (2007).


J. C. Rodríguez-Cabello, J. Reguera, A. Girotti, J. Arias, M. Alonso. “Genetic Engineering of Protein-Based Polymers: The Example of Elastin-like Polymers”Advances in Polymer Science, 200: 119-167 (2006).

A.C. Rincón, I. T. Molina-Martinez, B. de las Heras, M. Alonso, C. Baílez, J.C. Rodríguez-Cabello, R. Herrero-Vanrell.Biocompatibility of elastin-like polymer poly(VPAVG) microparticles: in vitro and in vivo studies”Biomed. Mater. Res. Part A, 78A (2): 343-351 (2006).

J. Arias, V. Reboto, S. Martín, I. López, J. C. Rodriguez-Cabello.Tailored recombinant elastin-like polymers for advanced biomedical and nano(bio)technological applications”Biotechnol Lett, 28:687–695 (2006).

J.C. Rodríguez-Cabello, S. Prieto, F.J. Arias, J. Reguera, and A. Ribeiro. “Nanobiotechnological approach to engineered biomaterial design: the example of elastin-like polymers”Nanomedicine, 1(3), 267-280 (2006).


R. Herrero-Vanrell, A. Rincón, M. Alonso, V. Reboto, I. Molina Martinez, J. C. Rodríguez-Cabello. “Self-assembled particles of an elastin-like polymer as vehicles for controlled drug release”Control. Release 102 (1): 113– 122 (2005).

P. Schmidt, J. Dybal, J.C. Rodríguez-Cabello and V. Reboto.The Role of Water in the Structural Changes of Poly(AVGVP) and Poly(GVGVP) Studied by FTIR and Raman Spectroscopy and ab initio Calculations”Biomacromolecules 6: 697-706 (2005).

J.C. Rodríguez-Cabello, J. Reguera, A. Girotti, M Alonso, A. M. Testera. “Developing functionality in elastin-like polymers by increasing their molecular complexity: The power of the genetic engineering approach”Prog. Polym. Sci. 30 (11): 1119-1145 (2005).

M. J. Capo, Y. Diebold, C. Garcia Vazquez, M. alonso, V. Reboto, I. T. Molina Martinez, J. C. Rodriguez Cabello, M. Calonge. “Development of a biopolymer-epithelium complex for ocular surface reconstruction”.  Investigative Ophthalmology & Visual Science 46: Art. N. 4990, 0146-0404. (2005).


J. Reguera, M. Alonso, A.M. Testera, I.M. López, S. Martín, J.C. Rodríguez-Cabello. “Effect of modified a, b, and g-cyclodextrins on the thermo-responsive behavior of the elastin-like polymer, poly(VPGVG)”Carbohydrate Polymers 57, 293–297 (2004)

J. Dybal, P. Schmidt, J. Kříž, D. Kurková, J.C.Rodriguez-Cabello, M. Alonso. “Role of Hydration in the Phase Transition of Polypeptides Investigated by NMR and Raman Spectroscopy.  Macromolecular Symposia, accepted for publication”Macromolecular Chemistry and Physics: Macromolecular Symposia 205: 143-150 (2004).

 J. C. Rodríguez-Cabello, J. Reguera, M. Alonso, T. M. Parker, D. T. McPherson, D. W. Urry“Endothermic and Exothermic Components of an Inverse Temperature Transition for Hydrophobic Association by TMDSC”Chem. Phys. Letts. 388: 127–131 (2004).

A. Girotti, J. Reguera, F.J. Arias, M. Alonso, A.M. Testera and J.C. Rodríguez-Cabello. Design and Bioproduction of a Recombinant Multi(bio)functional Elastin-like Protein Polymer Containing Cell Adhesion Sequences for Tissue Engineering PurposesMater. Sci. Mater. Med. 15 (4): 479-484 (2004).

A. Girotti, J. Reguera, J. Arias, M. Alonso, A. M. Testera, and J. C. Rodríguez-Cabello. “Influence of the Molecular Weight on the Inverse Temperature Transition of a Model Genetically Engineered Elastin-like pH-Responsive Polymer”Macromolecules, 37 (9): 3396-3400 (2004).

J. Reguera, J. C. Rodríguez-Cabello, A.Girotti, A. Wagih Fahmi, P. Moriarty. “Nanopore Formation by Self-Assembling of the Model Genetically Engineered Elastin-like Polymer [(VPGVG)2(VPGEG)(VPGVG)2]15Amer. Chem. Soc. 126: 13212-13213 (2004).

R. Herrero-Vanrell, A. C. Ricon, I. T. Molina-Martinez, M. F. Refojo, J. C. Rodriguez Cabello, M. Alonso. “Sustained Delivery of dexamethasone from Thermo-Responsive Poly (VPAVG) Microparticles”Investigative Ophthalmology & Visual Science 45, 0146-0404  (2004).

J. C. Rodriguez Cabello. Smart Elastin-Like Polymers”. Biomaterials: from Molecules to Engineered Tissues, 55345-57, 0065-2598, (2004).             


D. Kurková, J. Kříž , P. Schmidt, J. Dybal, J. C. Rodríguez-Cabello and M. Alonso.Structure and Dynamics of Two Elastin-like Polypentapeptides Studied by NMR Spectroscopy”Biomacromolecules, 4: 589-601 (2003).

J. Reguera, J. M. Lagarón, M. Alonso, V. Reboto, B. Calvo and J. C. Rodríguez-Cabello.“Thermal Behavior and Kinetic Analysis of the Chain Unfolding and Refolding and of the Concomitant Non-Polar Solvation and Desolvation of Two Elastin-like Polymers”Macromolecules, 36: 8470-8476 (2003).

R. Herrero-Vanrell, A. C. Ricon, I. T. Molina-Martinez, J. Reguera, M. Alonso, M. F. Refojo, J. C. Rodriguez Cabello. “Poly (VPAVG) as Potential Vehicle for Intaocular Drug Delivery Systems”Investigative Ophthalmology & Visual Science., Art. N 441, 0146-0404 (2003).


J. C. Rodríguez-Cabello, M. Alonso, L. Guiscardo, V. Reboto, A. Girotti. “Amplified Photoresponse of a p-Phenylazobenzene Derivative of an Elastin-like Polymer by a-Cyclodextrin: The Amplified δTt Mechanism”Advanced Materials 14(16): 1151-1154 (2002).

J. Dybal , P. Schmidt , D. Kurková , J. Kříž , J. C. Rodríguez-Cabello and M. Alonso. “Temperature Induced Conformational Transitions of Elastin-like Polypentapeptides Studied by Raman and NMR Spectroscopy”Spectroscopy 16: 251-255 (2002).


P. Schmidt, J. Dybal, J.C. Rodríguez-Cabello, M. Alonso. Raman Spectroscopy of the Secondary Structure of the Elastin-like Polymer Poly (GVGVP)”Biopolymers, 62: 150-157 (2001).

J. C. Rodríguez Cabello. Los Polímeros de Bioingeniería Molecular: Nuevos Polímeros Inteligentes y Bioactivos”Archivos de la Sociedad Española de Oftalmología, Mayo (2001). Editorial realizado por invitación.

M. Alonso, D. Arranz, V. Reboto and J. C. Rodríguez-Cabello. “Effect of a, b and g-Cyclodextrins on the Inverse Temperature Transition of the Bioelastic Thermo-responsive Polymer Poly(VPGVG)”. Macromol. Chem. Phys. 202(15): 3027-3034 (2001).

M. Alonso, V. Reboto, L. Guiscardo, V. Maté, J.C. Rodríguez-Cabello. “Novel Photoresponsive p-Phenylazobenzene Derivative of an Elastin-Like Polymer with Enhanced Control of Azo Content and without pH Sensitiveness”. Macromolecules 34(23): 8072-8077 (2001).


J.M. Lagarón, S. López-Quintana, J.C. Rodríguez-Cabello, J.C. Merino and J.M. Pastor.“Comparative Study of the Crystalline Morphology Present in Isotropic and Uniaxially Stretched “Conventional” and Metallocene Polyethylene”. Polymer, 41: 2999-3010 (2000).

J.C. Rodríguez-Cabello, M. Alonso, M.I. Caballero and M.M. Herguedas. “Experimental Study on the Assignation of Non-amide Raman Bands of the
Polypentapeptide of Elastin, Poly(VPGVG)”
Raman Spectroscopy, 31: 523-527 (2000).

J.C. Rodríguez-Cabello, M. Alonso, T. Pérez, and M. Mar Herguedas. Differential Scanning Calorimetry Study of the Hydrophobic Hydration of the Elastin-Based Polypentapeptide, Poly(VPGVG), from Deficiency to Excess of Water”Biopolymers, 54(4): 282-288 (2000).

M. Alonso, V. Reboto, L. Guiscardo, A. San Martín, J.C. Rodríguez-Cabello. “Spiropyran Derivative of an Elastin-like Bioelastic Polymer: Photoresponsive Molecular Machine to Convert Sunlight Into Mechanical Work”Macromolecules, 33(26): 9480-9482 (2000).


J.C. Rodríguez-Cabello, M. Alonso, M.I. Díez, M.I. Caballero, M.M. Herguedas. Structural Investigation of the Poly(pentapeptide) of Elastin, Poly(GVGVP), in the Solid State. Macromol. Chem. Phys., 200: 1831-1838 (1999).