You can review our publications in the following years:



J. Coletta, A. Ibáñez-Fonseca, L. R. Missana, M. V. Jammal, E. J. Vitelli, M. Aimone, F. Zabalza, J. P. Mardegan Issa, M. Alonso, J. C. Rodríguez-Cabello, S. Feldman. “Bone regeneration mediated by a bioactive and biodegradable ECM-like hydrogel based on elastin-like recombinamers”. Tissue Engineering Part A (2017, in press)

M. P. Sousa , I. Gonzalez de Torre,  M. B. Oliveira,  J. C. Rodríguez-Cabello, J. F. Mano.Biomimetic click assembled multilayer coatings exhibiting responsive properties”. Materials Today Chemistry (2017, in press)

M. Hamed Misbah, M.Santos, L. Quintanilla, C. Günter, M. Alonso, A. Taubert, J. C. Rodríguez-Cabello. “Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization”Beilstein Journal of Nanotechnology (2017 ,in press)

F.J. Arias, M. Santos, A. Ibáñez-Fonseca, MªJ. Piña, S. Serrano, “Elastin-like recombinamers as smart drug delivery systems” Current Drug Targets (2017) DOI: 10.2174/1389450117666160201114617

M.Santos, C. González-Obeso, D. Orbanic, E. Pérez del Río, F.J. Arias, “Advanced systems for controlled drug delivery from chemically modified Elastin-like Recombinamers” Current Organic Chemistry 21: 21-33 (2017)

A. Ibáñez-Fonseca, M. Alonso, F. J. Arias, J. C. Rodriguez-Cabello, “FRET-paired hydrogel forming silk-elastin-like recombinamers by recombinant conjugation of fluorescent proteins”Bioconjugate Chemistry (2017, in press)

J. P. Govindarahjulu, X. Chen, Y. Li, J. C. Rodriguez-Cabello, M. Battacharya, C.Aparicio. Chitosan-recombinamer layer-by-layer coatings for multifunctional implants”. International Journal of Molecular Sciences (2017Accepted for Publication)

Y. Li, J. C. Rodríguez-Cabello, C. Aparicio. “Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils. ACS Applied Materials & Interfaces (2017, in press). DOI: 10.1021/acsami.6b15285


13-Coacervation of elastin-like recombinamer microgels

S. Singh, D.E. Demco, K. Rahimi, R. Fechete, J.C. Rodriguez-Cabello, M. Möller.Coacervation of elastin-like recombinamer microgelsMacromolecular Rapid Communications;37(2):181-6 (2016). doi: 10.1002/marc.201500457

B. Barriuso,  P. Antolin,  F.J Arias F,  A. Girotti A,  P. Jimenez,  M. Cordoba-Diaz,  D. Cordoba-Diaz,  T. Girbes. “Anti-Human endoglin (hCD105) immunotoxin— Containing recombinant single chain ribosome- Inactivating protein musarmin”Toxins, 8, Issue 6 (2016)

A. Fernandez-Colino,  J.M. Bermudez,  F.J. Arias, D. Quinteros, E. Gonzo. “Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel”Materials Science and Engineering, 61, 286 – 292 (2016)

S. Poveda-Reyes, V. Moulisova, E. Sanmartín-Masiá, L. Quintanilla-Sierra, M. Salmerón-Sánchez, G. G. Ferrer. “Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation”. Macromol Biosciences; 16(9):1311-24 (2016) doi: 10.1002/mabi.201500469.

J.C. Rodríguez Cabello, I. González De Torre, M. Santos, A.M. Testera, M. Alonso. Chemical Modification of Biomaterials from Nature. In: Biomaterials from Nature for Advanced Devices and Therapies, pp.444-474. 2016. DOI: 10.1002/9781119126218.ch24

R. Kovacina, W. F. Daamen, D. Orbanić, J. C.s Rodríguez-Cabello, A. S Weiss. Elastin Biopolymers. In: Reference Module in Materials Science and Materials Engineering. 2016. DOI 10.1016/B978-0-12-803581-8.10187-0

Elastin-like polypeptides in drug delivery


J. C. Rodríguez-Cabello, F. J. Arias, M. Alonso, A. Girotti. Elastin-like polypeptides in drug deliveryAdvanced Drug Delivery Reviews 97, 85–100 (2016)

2016 (2)M. J. Piña, A. Girotti, M. Santos, J.C. Rodríguez-Cabello, F. J. Arias.Biocompatible ELR based polyplexes coated with MUC1 specific aptamers and targeted for breast cancer gene therapyMol Pharm, 13 (3), pp 795–808 (2016). doi: 10.1021/acs.molpharmaceut.5b00712


mohammedM. Hamed Misbah,  M. Espanol, L. Quintanilla, M. P. Ginebra, J. Carlos Rodríguez-Cabello. Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamersRSC Adv, 6, 31225 (2016)


X. Punet, R. Mauchauffé, M. Alonso, J. C. Rodríguez-Cabello, E. Engel, M. A. Mateos-Timoneda. “Biomolecular functionalization for enhanced cell-material interactions of poly (methyl methacrylate) surfaces”. Regenerative Biomaterials, 2015, 1-9. doi:10.1093/rb/rbv014

S. Singh, Dan E. Demco, K. Rahimi, R. Fechete, J. C. Rodríguez-Cabello, M. Möller.  Aggregation behaviour of biohybrid microgels from elastin-like recombinamerSoft Matter, 2016, Accepted Manuscript. doi: 10.1039/C6SM00954A.

I. Gonzalez de Torre, M. Weber, L. Quintanilla, M. Alonso, S. Jockenhoevel, J. C. Rodríguez Cabello, P. Mela. Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications. Biomater Sci. 2016; 4(9):1361-70. doi: 10.1039/c6bm00300a

M. Putzu, F. Causa, V. Nele, I. Gonzlez de Torre, J. C. Rodriguez-Cabello, P. Netti´. “Elastin-like-recombinamers multilayered nanofibrous scaffolds for cardiovascular applications”. In Press

M. Vila, A. García, A. Girotti, M. Alonso, J. C. Rodríguez-Cabello, A. González-Vázquez, J. A. Planell, E. Engel, J. Buján, N. García-Honduvilla, M. Vallet-Regí. 3D Silicon doped hydroxyapatite scaffolds decorated with elastin-like recombinamers for bone regenerative medicineActa Biomaterialia. 2016; 45: 349–356. Doi: 10.1016/j.actbio.2016.09.016


M. H. Misbah, L. Quintanilla, M. Alonso, J.C. Rodríguez-Cabello. “Evolution of Amphiphilic Elastin-like co-Recombinamer Morphologies From Micelles to a Lyotropic Hydrogel”Polymer 81, 37–44 (2015). doi:10.1016/j.polymer.2015.11.013

Y. Li, X. Chen, A. Fok, J.C. Rodriguez-Cabello, and C. Aparicio. Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Density. ACS Appl. Mater. Interfaces, 7(46): 25784-92. doi: 10.1021/acsami.5b07628

8-Amphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers. Cooperative Interplay between Both Domains Results in Injectable and Stable Hydrogels

A. Fernández-Colino, F. Javier Arias, M. Alonso, and J. Carlos Rodríguez-Cabello. Amphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers: Cooperative Interplay between Both Domains Results in Injectable and Stable HydrogelsBiomacromolecules, 16 (10), pp 3389–3398 (2015). doi: 10.1021/acs.biomac.5b01103.

A. Sánchez-Ferrero, A. Mata, M.A. Mateos-Timoneda, J.C. Rodríguez-Cabello, M. Alonso, J. Planell, E. Engel.Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regenerationBiomaterials, 68, 42-53 (2015). doi:10.1016/j.biomaterials. 2015.07.062 Epub 2015 Aug 3.

Punet, R. Mauchauffé, M. Alonso, J.C. Rodríguez-Cabello, E. Engel, M.A. Mateos-Timoneda.Biomolecular functionalization for enhanced cell-material interactions of poly (methyl methacrylate) surfacesRegenerative Biomaterials (2015) doi: 10.1093/rb/rbv014

10-Exploring the properties of genetically engineered silk-elastin-like protein films

R. Machado, A. da Costa, V. Secadas, A.M. Pereira, T. Collins, J.C. Rodríguez-Cabello, S. Lanceros-Méndez, M. Casal.Exploring the properties of genetically engineered silk-elastin-like protein filmsMacromolecular Bioscience (2015). doi: 10.1002/mabi.201500132.


6-Recombinant technology in the development of materials and systems for soft-tissue repair


A. Girotti, D. Orbanic, A. Ibáñez-Fonseca, C. González-Obeso, J.C. Rodríguez-Cabello.Recombinant technology in the development of materials and systems for soft-tissue repairAdv Healthc Mater (2015). doi: 10.1002/adhm.201500152.


9- Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers

J.C. Rodríguez-Cabello, M. Jesús Piña, A. Ibáñez-Fonseca, A. Fernández-Colino, and F.J. Arias.Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers. Bioconjugate Chem., 26 (7), pp 1252–1265 (2015), doi: 10.1021/acs.bioconjchem.5b00183.


K. Inostroza Brito, E. Collin, O. Siton-Mendelson, K. Smith, A. Monge-Marcet, D. Ferreira, R.Pérez Rodríguez, M. Alonso, J.C. Rodríguez-Cabello, R.Reis, F. Sagués, L. Botto, R. Bitton, H. Azevedo, and A. Mata.Co-assembly, spatio-temporal control, and morphogenesis of a hybrid protein/peptide system. Nature Chemistry 7, 897–904 doi:10.1038/nchem.2349

[Video] [Chemistryworld] []

V.E. Santo, S. Prieto, A.M. Testera, F.J. Arias, M. Alonso; J.F. Mano, J.C. Rodríguez-Cabello.Temperature-responsive bioactive hydrogels based on a multifunctional recombinant elastin-like polymerBiomaterials and biomedical engineering, 2 (1), 47-59 (2015). doi: http ://

M.J. Piña, S.M. Alex, F.J. Arias, M. Santos, J.C. Rodriguez-Cabello, R.M. Ramesan, C.P. Sharma. Elastin-like recombinamers with acquired functionalities for gene-delivery applicationsJounal of Biomedical Materials Research part. A. (2015), doi: 10.1002/jbm.a.35455.

A.M Testera, A. Girotti, I. González de Torre, L. Quintanilla, M. Santos,  M. Alonso, J.C. Rodríguez-Cabello.Biocompatible elastin-like click gels: design, synthesis and characterization. Journal of Materials Science: Materials in Medicine, 26 (2), 5435 (2015). doi:10.1007/s10856-015-5435-1.

3-Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applicationsM.I. Castellanos, A.-S. Zenses, A. Grau, J.C. Rodríguez-Cabello, F.J. Gil, J.M. Manero, M. Pegueroles.Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applicationsColloids and Surfaces B: Biointerfaces, 127, 22-32 (2015). doi: 10.1016/j.colsurfb.2014.12.056.

1-Elastin like recombinamer-covered stents. Towards a fully biocompatible and non-thrombogenic device for cardiovascular diseasesI. González de Torre, F. Wolf, M. Santos, L. Rongen, M. Alonso, S. Jockenhoevel, J.C. Rodríguez-Cabello, P. Mela.Elastin-like recombinamer-covered stents: towards a fully biocompatible and non-thrombogenic device for cardiovascular diseasesActa Biomaterialia, 12, 146-155 (2015). doi: 10.1016/j.actbio.2014.10.029.


Image for unlabelled figureA. Fernández-Colino, J. M. Bermudez,F. J. Arias, D. Quinteros, E. Gonzo.“Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel”Mater Sci Eng C Mater Biol Appl. 61, 286-92 (2016). doi: 10.1016/j.msec.2015.12.050.



E. Tejada-Montes, K.H. Smith, E. Rebollo, R. Gómez, M. Alonso, J.C. Rodriguez-Cabello, E. Engel, A. Mata. “Bioactive membranes for bone regeneration applications: effect of physical and biomolecular signals on mesenchymal stem cell behaviour”Acta Biomaterialia, 10, 134-141 (2014).

E. Salvagni, G. Berguig, E. Engel, J.-C. Rodriguez-Cabello, G. Coullerez, M. Textor, J.A. Planell, F.Javier Gil , Conrado Aparicio. A Bioactive Elastin-like Recombinamer Reduces Unspecific Protein Adsorption and Enhances Cell Response on Titanium Surfaces. Colloids and Surfaces B: Biointerfaces, 114, 225-233 (2014).

F. J. Arias, M. Santos, A. Fernandez-Colino, G. Pinedo and A. Girotti. “Recent contributions of elastin-like recombinamers to biomedicine and nanotechnology. Current Topics in Medicinal Chemistry, 14 (6), 819-36 (2014).

C. Kilic, A. Girotti, J.C. Rodriguez-Cabello, V. Hasirci. “A collagen-based corneal stroma substitute with micro-designed architecture”Biomaterials Science, 2, 318-329 (2014).

I. Gonzalez de Torre, A. Testera, L. Quintanilla, M. Santos, M. Alonso, J.C. Rodriguez-Cabello. “Elastin-like recombinamers catalyst-free click gels (ELRs-CFCGs).I: Characterization of poroelastic and intrinsic viscoelastic properties”Acta Biomaterialia, 10(6), 2495-505 (2014).

Rui R Costa, Alessandra Girotti, Mercedes Santos, Javier Arias, Joao F. Mano, J. Carlos Rodríguez-Cabello. “Cellular Uptake of Multilayered Capsules Produced With Natural and Genetically Engineered Macromolecules”Acta Biomaterialia, 10 (6), 2653-2662 (2014). doi: 10.1016/j.actbio.2014.02.020.

Yuping Li, Xi Chen, Artur J. Ribeiro, Eric D. Jensen, Kyle V. Holmberg, J.Carlos.Rodriguez-Cabello, C. Aparicio. “Hybrid nanotopographical surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers”Advanced Healthcare Materials, 3 (10), 1638-1647 (2014). 2014 Best Paper of the Year Award in Basic Sciences at the University of Minnesota School of Dentistry.

G. Pinedo-Martín, E. Castro, L. Martín, M. Alonso, J.C. Rodriguez-Cabello. “The effect of surfactants on the self-assembly of a model elastin-like block co-recombinamer: From micelles to an aqueous two-phase system”Langmuir, 30(12), 3432-40 (2014). doi: 10.1021/la500464v.

E. Tejeda-Montes, A. Klymov, M. Reza Nejadnik, M. Alonso, J.C. Rodriguez-Cabello, X.F. Walboomers, A. Mata. Mineralization and Bone regeneration using a bioactive elastin-like recombinamer membrane”Biomaterials, 35, 8339-8347 (2014).

I. González de Torre, L. Quintanilla, G. Pinedo-Martín, M. Alonso, J.C. Rodriguez-Cabello. “Nanogel Formation from Dilute Solutions of Clickable Elastin-Like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes”ACS Applied Materials & Interfaces, 6(16), 14509-14515 (2014).

G. Pinedo-Martín, M. Santos, A.M. Testera, M. Alonso, J.C. Rodríguez-Cabello. “The Effect of NaCI on the Self-assembly of elastin-like block co-recombinamers: Tuning the size of micelles and vesicles”Polymer, 55, 5314-5321 (2014).

A. Fernández-Colino, F.J. Arias, M. Alonso, J.C. Rodriguez-Cabello. “Self-organized ECM-mimetic model based on an amphiphilic multiblock silk-elastin-like co-recombinamer with a concomitant dual physical gelation process”Biomacromolecules 15 (10), 3781-3793 (2014). doi: 10.1021/bm501051t 5.750.


M. Gonzalez, E. Salvagni, J.C. Rodriguez Cabello, E. Rupérez, Fco. J. Gil, J. Peña, J.M. Manero. “A low elastic modulus Ti-Nb-Hf alloy bioactivated with an elastin-like protein-based polymer enhances osteoblast cell adhesion and spreading”Biomed Mater Res Part A, 101 (3), 819-826 (2013). doi: 10.1002/jbm.a.34388.

Rui R. Costa, Artur J. Ribeiro, J.C. Rodriguez-Cabello, J.F. Mano. “Nanostructured thin coatingS from chitosan and an elastin-like recombinamer with acute stimuli-responsive behaviour”Advanced Materials Forum Vi, Pts 1 And 2. Book Series: Materials Science Forum, Vols. 730-732, 32-37 (2013).

C. García-Arévalo, J.F. Bermejo Martín, L. Rico, V. Iglesias, L. Martín, J.C. Rodriguez-Cabello, F.J. Arias.  Immunomodulatory nanoparticles form elastin-like recombinamers: single-molecules for tuberculosis vaccine development. Molecular Pharmaceutics, 10(2), 586-97 (2013). doi: 10.1021/mp300325v.

R. Machado, J. Azevedo-Silva, C. Correia, T. Collins, F.J. Arias, J.C. Rodríguez-Cabello, M. Casal. “High level expression and facile purification of recombinant silk-elastin-like polymers in auto induction shake flask cultures”AMB Express, 3(1), 11 (2013). doi: 10.1186/2191-0855-3-11.

R.R. Costa, C.A. Custódio, F.J. Arias, J.C. Rodríguez-Cabello, J.F. Mano. “Nanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules”Nanomedicine: Nanotechnology, Biology, and Medicine, 9, 895-902 (2013).

M. Pierna, M. Santos, F.J. Arias, M. Alonso, J.C. Rodriguez-Cabello. “Efficient cell and cell-sheet harvesting based on smart surfaces coated with a multifunctional and self-organizing Elastin-Like Recombinamer”Biomacromolecules, 14, 1893-1903 (2013).

R.R. Costa, A. Testera, F.J. Arias, J.C. Rodríguez-Cabello, J. Mano. “Layer-by-Layer Film-Growth Using Polysaccharides and Recombinant Polypeptides: A Combinatorial Approach”The Journal of Physical Chemistry B, 117(22), 6839-6848 (2013).

R.R. Costa, E. Castro, F.J. Arias, J.C. Rodríguez-Cabello, J. Mano. “Multifunctional Compartmentalized Capsules with a Hierarchical Organization from the Nano to the Macro Scales”Biomacromolecules, 14, 2403-2410 (2013).

X. Punet, R. Mauchauffé, M. Giannotti, J.C. Rodríguez-Cabello, F. Sanz, E. Engel, M.A. Mateos-Timoneda, J. Planell. “Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces”Biomacromolecules, 14 (8), 2690-2702 (2013).

R. Machado, A. da Costa, V. Sencadas, C. García-Arévalo, C. Costa, J. Padrao, A. Gomes, S. Lanceros-Mendez, J.C. Rodriguez-Cabello, M. Casal. “Electrospun silk-elastin-like fiber mats for tissue engineering applications”Biomedical Materials, 8 (6), 065009 (2013).


C. Garcia-Arévalo, M. Pierna Alvarez, A. Girotti, F.J. Arias Vallejo, J.C. Rodriguez-Cabello. “A comparative study of cell behavior on energetic and bioactive different polymeric surfaces made from elastin-like recombinamers”Soft Matter, 8 (11), 3239-3249 (2012).

L. Martín, E. Castro, A. Ribeiro, M. Alonso, J.C. Rodriguez-Cabello.Temperature-Triggered Self-Assembly of elastin-like block co-recombinamers: the controlled formation of micelles and vesicles in aqueous medium”Biomacromolecules, 13, 293-298 (2012).

S. Nardecchia, M. Gutierrez, M. Ferrer, M. Alonso, I. Lopez, J.C. Rodríguez Cabello, F. del Monte. “Phase Behaviour of Elastin-Like Synthetic Recombinamers in Deep Eutectic Solvents”Biomacromolecules, 13(7), 2029-2036 (2012).


J.C. Rodriguez-Cabello, L. Martín, A. Girotti, C. García-Arévalo, F.J. Arias, M. Alonso. “Emerging Applications of Multifunctional Elastin-Like Recombinamers”Nanomedicine, Vol 6, 1, 111-122 (2011).

G.K. Srivastava, L. Martín, A.K. Singh, I. Fernandez-Bueno, M.J. Gayoso, M.T. Garcia-Gutierrez, A. Girotti, M. Alonso, J.C. Rodríguez-Cabello, J.C. Pastor. “Elastin-like recombinamers as substrates for retinal pigment epithelial (RPE) cell growth”Journal of Biomedical Materials Research: Part A, 97A, 243-250 (2011). doi: 10.1002/jbm.a.33050.

M. Golonka, M. Bulwan, M. Nowaskowska, A.M. Testera, J.C. Rodriguez-Cabello, S. Zapotoczny“Thermoresponsive multilayer films based on ionic elastin-like recombinamers”Soft matter, 7, 9402-9409 (2011).

S. Prieto, A. Shkilnyy, C. Rumplasch, A. Ribeiro, F.J. Arias, J.C. Rodriguez-Cabello, A. Taubert. Biomimetic calcium phosphate mineralization with multifunctional elastin-like recombinamers”Biomacromolecules.Vol 5, 1480-1486 (2011).

B. Kinikoglu, J.C. Rodríguez-Cabello, O. Damour, V. Hasirci. “A smart bilayer scaffold of elastin-like recombinamer and collagen for soft tissue engineering”J Mater Sci Mater Med., 22, 1541-1554 (2011).

J.C. Rodríguez-Cabello, M. Pierna, A. Fernández Colino, C. García-Arévalo, F.J. Arias Vallejo. “Recombinamers: Combining Molecular Complexity with Diverse Bioactivities for Advanced Biomedical and Biotechnological Applications”Advances in Biochemical Engineering/Biotechnology, 125, 145-179 (2011).

M.B. Oliveira, W. Song, L. Martín, S.M. Oliveira, S.G. Caridade, M. Alonso, J.C. Rodriguez-Cabello, J.F. Mano. “Development of an injectable system based on elastin-like recombinamer particles for tissue engineering applications”Soft Matter, 7, 6426-6434 (2011).

B. Kinikoglu, J.C, Rodríguez-Cabello, O. Damour, V. Hasirci. “The Influence of Elastin-like recombinant polymer significantly increases the self-renewing potential of a 3D tissue equivalent Derived From Human Lamina Propria Fibroblasts And Oral Epithelial Cells”Biomaterials, 32, 5756-5764 (2011).

R.R. Costa, F.J. Arias, J.C. Rodriguez-Cabello, J.F. Mano. “Temperature-responsive microcapsules prepared by nano-structured multilayers of chitosan and elastin-like recombinamer for the controlled release of therapeutic molecules”International journal of artificial organs, 34, 656-657 (2011).

R.R. Costa, C.A. Custódio, F.J. Arias, J.C. Rodríguez Cabello, J.F. Mano. “Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli responsive properties”. Small ,Vol. 7, 2640-2649 (2011). doi: 10.1002/smll.201100875.

A. Girotti, A. Fernández-Colino, I.M. López, J.C. Rodríguez-Cabello, F.J. Arias. “Elastin-like Recombinamers: Biosynthetic Strategies and Biotechnological Applications”Biotechnol J.,6 (10), 1174-1186 (2011). doi: 10.1002/biot.201100116.


P.C. Bessa, R. Machado, S. Nürnberger, D. Dopler, A. Banerjee, A.M. Cunha, J.C. Rodríguez-Cabello, H. Redl, M. van Griensven, R.L. Reis, M. Casal. “Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs”Journal of Controlled Release, 142, 312-318 (2010).

R. Alvarez-Rodríguez, F.J. Arias, M. Santos, A. M. Testera, J.C. Rodríguez-Cabello. Gold Tailored Photosensitive Elastin-Like Polymer: Synthesis of Temperature, pHand UV-VIS Sensitive Probes”Macromolecular Rapid Communications, 31, 568-573 (2010).

J.S. Barbosa, A.M. Testera, M. Alonso,F.J. Arias, J.C. Rodríguez-Cabello,J.F.Mano. “Development of Biomimetic Chitosan Based Hydrogels Using an Elastin Like Polymer”Advanced Engineering Materials, 12, B37-B44 (2010).

A. Fahmi, T. Pietsch, M. Bryszewsk, J.C. Rodríguez-Cabello, A. Koceva-Chyla, F.J. Arias, M. Alonso and N. Gindy. “Fabrication of CdSe-Nanofibres with Potential for Biomedical Applications”Advanced Functional Materials, 20, 1011-1018 (2010).

R. Álvarez-Rodriguez, M. Alonso, A. Girotti, V. Reboto, J.C. Rodríguez Cabello. “One pot Synthesis of pH and Temperature Sensitive Gold Clusters Mediated by a Recombinant Elastin-Like Polymer”European Polymer Journal, 46, 643-650 (2010).

L. Martín, F.J. Arias, M. Alonso, C. García-Arévalo and J.C. Rodríguez-Cabello.“Rapid micropatterning by temperature-triggered reversible gelation of a recombinant smart elastin-like tetrablock-copolymer”Soft Matter, 6, 1121-1124 (2010).


H. Martínez-Osorio, M. Juárez-Campo, Y. Diebold, A. Girotti, M. Alonso, J. Arias, J.C. Rodríguez-Cabello, C. García-Vázquez, M. Calonge.“Genetically engineered elastin-like polymer as a substratum to culture cells from the ocular surface”NCER: Current Eye Research. 34, 48-56. ISSN: 0271-3683 (2009).

Y. García, N. Hemantkumar, R. Collighan, M. Griffin, J.C. Rodriguez-Cabello and A. Pandit. “In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer”Tissue Engineering Part A Vol. 15, 4, 887-899 (2009). doi: 10.1089.

L. Martín, M. Alonso, M. Möller, J.C. Rodríguez-Cabello, P. Mela. “3D microstructuring of smart bioactive hydrogels based on recombinant elastin-like polymers”Soft Matter, 5, 1591-1593. doi: 10/1039/b823488d (2009).

R. Araujo, C. Silva, R. Machado, M. Casal, A. Cunha, J.C. Rodríguez Cabello, A. Cavaco-Paulo. “Proteolytic enzyme engineering: a tool for wool”Biomacromolecules, 10, 1655-1661 (2009).

A. Ribeiro, F. Javier Arias, J. Reguera, M. Alonso, J. C. Rodriguez-Cabello. “BIOAVAN. Subproyecto 1. Funcionalización de polímeros para la fabricación de productos biomédicos avanzados. Subproyecto del PSE-300000-2008-1”Biophysycal Journal,Vol. 97, July, 312-320 (2009). ISSN: 0006-3495.

C. García-Arévalo, A. Girotti, F.J. Arias, S. Martín, I.M. López, J.C. Rodriguez-Cabello. “Obtención de un polímero de tipo Elastina modificado con secuencias Bioactivas y Biodegradables, para su aplicación en ingeniería”. Accésit a la mejor comunicación del XXXI Simposio de la Sociedad Ibérica de Biomecánica y Biomateriales. Biomecánica,17, 15-27 (2009).

R. Machado, A. J. Ribeiro, J. Padrão, D. Silva, A. Nobre, J. A. Teixeira, F. J. Arias, A. M. Cunha, J. C. Rodríguez-Cabello and M. Casal. “Exploiting the sequence of naturally occurring elastin: Construction, production and characterization of a recombinant thermoplastic proteinbased polymer”Journal of Nano Research 6, 133-145 (2009).

C.  Aparicio, E. Salvagni, M. Werner, E. Engel, M. Pegueroles, J.C. Rodríguez-Cabello, F. Muñoz, J.A. Planell, J. Gil. “Biomimetic Treatments on Dental Implants for Immediate Loading Applications”Journal of Medical Devices. Volume 3,  Issue 2, pag.27555 (2009).

N. Ozturk, A. Girotti, G. Torun Kose, J. C. Rodríguez-Cabello, V. Hasirci.Dynamic Cell Culturing and its Application to Micropatterned, Eslastin like Protein-Modified Poly(N-Isopropylacrylamide ) Scaffolds”Biomaterials, 30, 5417-5426 (2009).

J.S. Barbosa, R.R. Costa, A.M. Testera, M. Alonso, J.C. Rodríguez-Cabello, J.F. Mano. “Multi-layered Films Containing a Biomimetic Stimuli-Responsive Recombinant Protein”Nanoscale Research Letters, 4, 1247-1253 (2009).

R.R. Costa, C.A. Custódio, A.M Testera, F.J. Arias, J.C. Rodríguez-Cabello, N.M. Alves and J.F. Mano. “Stimuli-Responsive Thin Coatings Using Elastin-Like Polymers for Biomedical Applications”Advanced Functional Materials , 19, 3210-3218 (2009).

J.C. Rodríguez-Cabello, L .Martín, M. Alonso, F. Javier Arias, Ana M. Testera. “Recombinamers’’ as advanced materials for the post-oil age”Polymer.Vol. 50, Issue 22, 5159-5169 (2009). Invited Feature Paper.

L. Martín, M. Alonso, A. Girotti, F. Javier. Arias, J. C. Rodriguez-Cabello. “Synthesis and Characterization of Macroporous Thermo Sensitive Hydrogels from Recombinant Elastin-Like Polymers”Biomacromolecules, 10, 3015-3022 (2009). ID: bm-2009-00560a. R2.

A. Ribeiro, F.J. Arias, J. Reguera, M. Alonso, and J.C. Rodríguez-Cabello. “Influence of the Molecular Architecture on the Inverse Temperature Transition of Elastin-Like Polymers”Biophys J. 97 (1), 312–320 (2009). doi:  10.1016/j.bpj.2009.03.030


Y. Garcia, H. Naik, R. Collighan, M. Griffin, J.C. Rodriguez-Cabello , A. Pandit. “Preferential cellular Behaviour is Seen with a Collagen-Elastin Like Polipeptide scaffold”.  Tissue Engineering Part A ISSN, 1937-3341, vol.14 – 5.pag. 769 (2008).

A. Girotti, F.J. Arias Vallejo, M Alonso, A.M. Testera, J. C. Rodriguez- Cabello. “Synthesis and Charactertization of Matrix Metalloprotease-Sensitive Elastin-Like Based Bioactive Hydrogels”Tissue Engineering Part A, ISSN 1937-3341, vol.14 – 5.pag.783-784 (2008).

R. R. Costa, A.M. Testera, F.J. Arias, J.F. Mano, J.C. Rodriguez-Cabello.Development of Biomimetic and Smart Coatings Based on Elastin-Like Polymers Coating RGD Cell Attachment sequences”Tissue Engineering Part A, ISSN 1937-3341, vol.14–5. pag.837 (2008).

J.S. Barbosa, A.M. Testera, M. Alonso, J.F. Mano, J.C. Rodriguez-Cabello. “Preparation of Temperature-responsive Matrices with Osteoinductive Behaviour Combining an Elastin-Like Polymer and Chitosan”Tissue Engineering Part A, ISSN 1937-3341, vol.14 – 5. pag.898 (2008).

V. Espírito Santo, S. Prieto, A. M. Testera, M. Alonso, F.J. Arias, J. F. Mano, J. C. Rodriguez-Cabello. “Physical Properties of an Artificial extracellular Matrix Based on a Crosslinked Elastin-like Polymer”Material Science Forum Vols. 587-588, 47-51 (2008).


D. Kurková, J. Kříž, J. C. Rodríguez-Cabello, and F. Javier Arias.NMR Study of a Cooperative Behavior of Thermotropic Model Polypeptides”Polymer International, 56 (2), 186-194 (2007). 

J. C. Rodríguez-Cabello, S. Prieto, J. Reguera, F. Javier Arias, A. Ribeiro.Biofunctional design of elastin-like polymers for advanced applications in nanobiotechnology”J. Biomater. Sci. Polymer Edn., 18(3), 269-286 (2007).

J. Reguera, D.W. Urry, T.M. Parker, D.T. McPherson, J.C. Rodríguez-Cabello.“Effect of NaCl on the Exothermic and Endothermic Components of the Inverse Temperature Transition of a Model Elastin-like Polymer”Biomacromolecules, 8(2), 354-358 (2007).


J. C. Rodríguez-Cabello, J. Reguera, A. Girotti, J. Arias, M. Alonso. “Genetic Engineering of Protein-Based Polymers: The Example of Elastin-like Polymers”Advances in Polymer Science, 200: 119-167 (2006).

A.C. Rincón, I. T. Molina-Martinez, B. de las Heras, M. Alonso, C. Baílez, J.C. Rodríguez-Cabello, R. Herrero-Vanrell.Biocompatibility of elastin-like polymer poly(VPAVG) microparticles: in vitro and in vivo studies”Biomed. Mater. Res. Part A, 78A (2): 343-351 (2006).

J. Arias, V. Reboto, S. Martín, I. López, J. C. Rodriguez-Cabello.Tailored recombinant elastin-like polymers for advanced biomedical and nano(bio)technological applications”Biotechnol Lett, 28:687–695 (2006).

J.C. Rodríguez-Cabello, S. Prieto, F.J. Arias, J. Reguera, and A. Ribeiro. “Nanobiotechnological approach to engineered biomaterial design: the example of elastin-like polymers”Nanomedicine, 1(3), 267-280 (2006).


R. Herrero-Vanrell, A. Rincón, M. Alonso, V. Reboto, I. Molina Martinez, J. C. Rodríguez-Cabello. “Self-assembled particles of an elastin-like polymer as vehicles for controlled drug release”Control. Release 102 (1): 113– 122 (2005).

P. Schmidt, J. Dybal, J.C. Rodríguez-Cabello and V. Reboto.The Role of Water in the Structural Changes of Poly(AVGVP) and Poly(GVGVP) Studied by FTIR and Raman Spectroscopy and ab initio Calculations”Biomacromolecules 6: 697-706 (2005).

J.C. Rodríguez-Cabello, J. Reguera, A. Girotti, M Alonso, A. M. Testera. “Developing functionality in elastin-like polymers by increasing their molecular complexity: The power of the genetic engineering approach”Prog. Polym. Sci. 30 (11): 1119-1145 (2005).

M. J. Capo, Y. Diebold, C. Garcia Vazquez, M. alonso, V. Reboto, I. T. Molina Martinez, J. C. Rodriguez Cabello, M. Calonge. “Development of a biopolymer-epithelium complex for ocular surface reconstruction”.  Investigative Ophthalmology & Visual Science 46: Art. N. 4990, 0146-0404. (2005).


J. Dybal, P. Schmidt, J. Kříž, D. Kurková, J.C.Rodriguez-Cabello, M. Alonso. “Role of Hydration in the Phase Transition of Polypeptides Investigated by NMR and Raman Spectroscopy.  Macromolecular Symposia, accepted for publication”Macromolecular Chemistry and Physics: Macromolecular Symposia 205: 143-150 (2004).

 J. C. Rodríguez-Cabello, J. Reguera, M. Alonso, T. M. Parker, D. T. McPherson, D. W. Urry“Endothermic and Exothermic Components of an Inverse Temperature Transition for Hydrophobic Association by TMDSC”Chem. Phys. Letts. 388: 127–131 (2004).

A. Girotti, J. Reguera, F.J. Arias, M. Alonso, A.M. Testera and J.C. Rodríguez-Cabello. Design and Bioproduction of a Recombinant Multi(bio)functional Elastin-like Protein Polymer Containing Cell Adhesion Sequences for Tissue Engineering PurposesMater. Sci. Mater. Med. 15 (4): 479-484 (2004).

A. Girotti, J. Reguera, J. Arias, M. Alonso, A. M. Testera, and J. C. Rodríguez-Cabello. “Influence of the Molecular Weight on the Inverse Temperature Transition of a Model Genetically Engineered Elastin-like pH-Responsive Polymer”Macromolecules, 37 (9): 3396-3400 (2004).

J. Reguera, J. C. Rodríguez-Cabello, A.Girotti, A. Wagih Fahmi, P. Moriarty. “Nanopore Formation by Self-Assembling of the Model Genetically Engineered Elastin-like Polymer [(VPGVG)2(VPGEG)(VPGVG)2]15Amer. Chem. Soc. 126: 13212-13213 (2004).

R. Herrero-Vanrell, A. C. Ricon, I. T. Molina-Martinez, M. F. Refojo, J. C. Rodriguez Cabello, M. Alonso. “Sustained Delivery of dexamethasone from Thermo-Responsive Poly (VPAVG) Microparticles”Investigative Ophthalmology & Visual Science 45, 0146-0404  (2004).

J. C. Rodriguez Cabello. Smart Elastin-Like Polymers”. Biomaterials: from Molecules to Engineered Tissues, 55345-57, 0065-2598, (2004).             


D. Kurková, J. Kříž , P. Schmidt, J. Dybal, J. C. Rodríguez-Cabello and M. Alonso.Structure and Dynamics of Two Elastin-like Polypentapeptides Studied by NMR Spectroscopy”Biomacromolecules, 4: 589-601 (2003).

J. Reguera, J. M. Lagarón, M. Alonso, V. Reboto, B. Calvo and J. C. Rodríguez-Cabello.“Thermal Behavior and Kinetic Analysis of the Chain Unfolding and Refolding and of the Concomitant Non-Polar Solvation and Desolvation of Two Elastin-like Polymers”Macromolecules, 36: 8470-8476 (2003).

R. Herrero-Vanrell, A. C. Ricon, I. T. Molina-Martinez, J. Reguera, M. Alonso, M. F. Refojo, J. C. Rodriguez Cabello. “Poly (VPAVG) as Potential Vehicle for Intaocular Drug Delivery Systems”Investigative Ophthalmology & Visual Science., Art. N 441, 0146-0404 (2003).


J. C. Rodríguez-Cabello, M. Alonso, L. Guiscardo, V. Reboto, A. Girotti. “Amplified Photoresponse of a p-Phenylazobenzene Derivative of an Elastin-like Polymer by a-Cyclodextrin: The Amplified δTt Mechanism”Advanced Materials 14(16): 1151-1154 (2002).

J. Dybal , P. Schmidt , D. Kurková , J. Kříž , J. C. Rodríguez-Cabello and M. Alonso. “Temperature Induced Conformational Transitions of Elastin-like Polypentapeptides Studied by Raman and NMR Spectroscopy”Spectroscopy 16: 251-255 (2002).


P. Schmidt, J. Dybal, J.C. Rodríguez-Cabello, M. Alonso. Raman Spectroscopy of the Secondary Structure of the Elastin-like Polymer Poly (GVGVP)”Biopolymers, 62: 150-157 (2001).

J. C. Rodríguez Cabello. Los Polímeros de Bioingeniería Molecular: Nuevos Polímeros Inteligentes y Bioactivos”Archivos de la Sociedad Española de Oftalmología, Mayo (2001). Editorial realizado por invitación.

M. Alonso, D. Arranz, V. Reboto and J. C. Rodríguez-Cabello. “Effect of a, b and g-Cyclodextrins on the Inverse Temperature Transition of the Bioelastic Thermo-responsive Polymer Poly(VPGVG)”. Macromol. Chem. Phys. 202(15): 3027-3034 (2001).

M. Alonso, V. Reboto, L. Guiscardo, V. Maté, J.C. Rodríguez-Cabello. “Novel Photoresponsive p-Phenylazobenzene Derivative of an Elastin-Like Polymer with Enhanced Control of Azo Content and without pH Sensitiveness”. Macromolecules 34(23): 8072-8077 (2001).


J.M. Lagarón, S. López-Quintana, J.C. Rodríguez-Cabello, J.C. Merino and J.M. Pastor.“Comparative Study of the Crystalline Morphology Present in Isotropic and Uniaxially Stretched “Conventional” and Metallocene Polyethylene”. Polymer, 41: 2999-3010 (2000).

J.C. Rodríguez-Cabello, M. Alonso, M.I. Caballero and M.M. Herguedas. “Experimental Study on the Assignation of Non-amide Raman Bands of the
Polypentapeptide of Elastin, Poly(VPGVG)”
Raman Spectroscopy, 31: 523-527 (2000).

J.C. Rodríguez-Cabello, M. Alonso, T. Pérez, and M. Mar Herguedas. Differential Scanning Calorimetry Study of the Hydrophobic Hydration of the Elastin-Based Polypentapeptide, Poly(VPGVG), from Deficiency to Excess of Water”Biopolymers, 54(4): 282-288 (2000).

M. Alonso, V. Reboto, L. Guiscardo, A. San Martín, J.C. Rodríguez-Cabello. “Spiropyran Derivative of an Elastin-like Bioelastic Polymer: Photoresponsive Molecular Machine to Convert Sunlight Into Mechanical Work”Macromolecules, 33(26): 9480-9482 (2000).


J.C. Rodríguez-Cabello, M. Alonso, M.I. Díez, M.I. Caballero, M.M. Herguedas. Structural Investigation of the Poly(pentapeptide) of Elastin, Poly(GVGVP), in the Solid State. Macromol. Chem. Phys., 200: 1831-1838 (1999).